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Traditional bone setting has existed from time immemorial in most African communities and had formed part of African culture. The preservation of traditional bone setting (TBS) skills among Nkpologu and Uvuru communities in Uzo Uwani LGA of Enugu state formed the focus of the study. A qualitative research approach was adopted in the study using an in-depth interview as a means of data gathering. The population of the study comprises of the three famous bone setters in Nkpologu and Uvuru respectively and few clients available in their clinics at the time of the study. The researchers visited the practitioners one on one to elicit information on the origin of bone setting in Nkpologu and Uvuru people; the skills required in bone setting; The health implication of bone setting in the area; the challenges encountered in traditional bone setting; and the preservation strategies for traditional bone setting in Nkpologu and Uvuru. The study revealed that the practice of bone setting is usually from ancestral heritage while others tagged the knowledge to revelation through dreams or trance and apprenticeship. The practice had affected many lives positively in the places and beyond. The challenges facing the TBS in the areas of study includes derogation from the orthodox practitioners, and mal practice among some practitioner, the researchers recommend among other things that a regulatory body be set up by the government to oversee the affairs of these practitioners.