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This study investigates the extent of publication output and functional areas of Library and Information Science (LIS) professionals. The research has been undertaken based on the primary data collected from the LIS professionals working in the various eight-state universities in Kerala, India. The population of the study consists of two hundred and sixty-six regular LIS professionals. The Census method was used for the collection of data. A questionnaire was designed and used as the instrument for extracting publication output and the relevant data. Based on the data analysis, the results show that the highest mean score for the publications of LIS professionals is in the conference papers followed by journal articles. It was also observed that the main primary functional area of most LIS professionals is in the circulation section, followed by the maintenance section and reference section.