The study includes a review of curriculum development in Library and Information Science Education (LISE) in Nigerian Universities: Issues and Prospects. Analysis on curriculum development were given (history of curriculum development, types of curricula and usefulness of curriculum development for educators and challenges of curriculum development). Curriculum development is core issue in the feasibility and growth of any discipline, library and information science education inclusive. Modern day librarianship, that is 21st century library and information science education (LISE) should integrate full information and communication technology programmes and not just computer application for professional efficiency and global acceptability. Therefore, curriculum of LIS in Nigerian Universities should be reviewed both at undergraduate and postgraduate level.