Mechanical & Materials Engineering, Department of


Date of this Version



Lin and Gu, J Biosens Bioelectron 2016, 7:1


© 2016 Lin S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License


The extracellular matrix (ECM) is essential for regulating cell behavior and tissue function [1]. Local ECM structure and mechanics are increasingly recognized as important mechanical effectors of cell responses and tissue regeneration [2]. This is illustrated by the fact that either the rigidity of ECM [3] or local tension regulate cellular mechanotransduction pathways, and their dysregulation results in many different types of diseases [4,5]. It was speculated that cell contractions, generated by the cross-bridging interaction of actin and myosin II motors, maintain a tensional homeostasis in response to mechanical disturbance. The question is what is exactly the tensional homeostasis, if any?