Mechanical & Materials Engineering, Department of


Date of this Version



EuroIntervention 2018; Jaa-347 2018


Copyright 2018 EuroIntervention

DOI: 10.4244/EIJ-D-17-01028


Advanced coronary atherosclerosis assessed by in-vivo optical coherence tomography (OCT) has not been directly compared with histology. In a porcine model with human-like coronary atherosclerosis we compared in-vivo OCT images with histology in five animals. We found a high sensitivity but modest specificity of OCT in classifying fibrous cap atheroma (FCA). The modest specificity was caused by misclassification of FCA lesions as pathological intimal thickening. The misclassification most frequently occurred when plaque burden exceeded ~20%. Compared with histology, OCT has high sensitivity but modest specificity for identifying FCA. The study suggests that plaque burden should be considered when interpreting OCT images.