Geographic variation in the PRNP gene and its promoter, and their relationship to chronic wasting disease in North American deer

Authors

Robert M. Zink, University of Nebraska - LincolnFollow
Nadje Najar, University of Nebraska - Lincoln
Hernan Vazquez-Miranda, University of Nebraska-Lincoln & Universidad Nacional Autónoma de México, Ciudad de México
Brittaney Buchanan, University of Nebraska-LincolnFollow
John Loy, University of Nebraska-LincolnFollow
Bruce W. Brodersen, University of Nebraska - LincolnFollow

ORCID IDs

http://orcid.org/0000-0002-4275-6979

http://orcid.org/0000-0001-6185-7831

http://orcid.org/0000-0001-5080-9228

Document Type

Article

Date of this Version

2020

Citation

PRION 2020, VOL. 14, NO. 1, 185–192 https://doi.org/10.1080/19336896.2020.1796250

Comments

2020 The Author(s).

Abstract

PRNP genotypes, number of octarepeats (PHGGGWGQ) and indels in the PRNP promoter can influence the progression of prion disease in mammals. We found no relationship between presence of promoter indels in white-tailed deer and mule deer from Nebraska and CWD presence. White-tailed deer with the 95 H allele and G20D mule deer were more likely to be CWD- free, but unlike other studies white-tailed deer with the 96S allele(s) were equally likely to be CWD-free. We provide the first information on PRNP genotypes and indels in the promoter for Key deer (all homozygous 96SS) and Coues deer (lacked 95 H and 96S alleles, but possessed a uniquely high frequency of 103 T). All deer surveyed were homozygous for three tandem octarepeats.