Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice

Authors

Vishnupriya Gourineni, University of Florida
Neil F. Shay, Oregon State UniversityFollow
Soonkyu Chung, University of Nebraska-LincolnFollow
Amandeep K. Sandhu, University of FloridaFollow
Liwei Gu, University of FloridaFollow

Document Type

Article

Date of this Version

2012

Citation

Published in Journal of Agricultural and Food Chemistry 60 (2012), pp. 7674−7681. doi 10.1021/jf3013663

PMID: 22788667

Comments

Copyright © 2012 American Chemical Society. Used by permission.

Abstract

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, triglycerides, and cholesterol in obese mice. Inflammation was alleviated, and activity of glutathione peroxidase was enhanced. Consumption of MGP or MWP improved insulin sensitivity and glucose control in mice. Thus, consumption of muscadine grape and wine phytochemicals in the diet may help to prevent obesity-related metabolic complications.