Nutrition and Health Sciences, Department of
Document Type
Article
Date of this Version
2012
Citation
PLoS ONE 7(4): e34921
Abstract
Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anticancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORa. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.
Included in
Human and Clinical Nutrition Commons, Molecular, Genetic, and Biochemical Nutrition Commons, Other Nutrition Commons
Comments
Copyright 2012 Wang et al
Open access
doi:10.1371/journal.pone.0034921