γ-Glutamyl Valine, Found in Dry Edible Beans, Is Anti-diabetic in db/db Mice

Authors

Bikram Upadhyaya, University of Nebraska-LincolnFollow
Kaustav Majumder, University of Nebraska - LincolnFollow
Regis Moreau, University of Nebraska–LincolnFollow

Document Type

Article

Date of this Version

2022

Citation

Curr Dev Nutr. 2022 Jun; 6(Suppl 1): 339. Published online 2022 Jun 14.

doi: 10.1093/cdn/nzac053.080

PMCID: PMC9193758

Abstract

Objectives: Dietary γ -glutamyl peptides (γ -GPs) found in dry edible beans exhibit biological activities (antioxidant, anti-inflammatory) with potential benefits against chronic metabolic disorders. γ -GPs are responsible for the desirable Kokumi flavor through allosteric activation of the Calcium Sensing Receptor (CaSR) present in multiple mammalian tissues. In this study, we investigated the metabolic effects of γ -glutamyl valine (γ -EV) in diabetic obese mice.

Conclusions: γ -EV improved the diabetic condition of db/db mice via modulation of glucose and lipid metabolism.