Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development

Authors

• Maranda Thompson, University of Nebraska Medical Center
• Arzu Ulu, University of California Riverside
• Maheswari Mukherjee, University of Nebraska Medical Center
• Ana G. Yuil-Valdes, University of Nebraska Medical Center,
• Melissa Thoene, University of Nebraska Medical Center
• Matthew Van Ormer, University of Nebraska Medical Center
• Rebecca Slotkowski, University of Nebraska Medical Center
• Teri Mauch, University of Nebraska Medical Center
• Ann Anderson-Berry, University of Nebraska Medical Center
• Corrine K. Hanson, University of Nebraska Medical Center
• Tara M. Nordgren, University of California Riverside, Colorado State University
• Sathish Kumar Natarajan, University of Nebraska - LincolnFollow

Document Type

Article

Date of this Version

1-10-2023

Citation

Thompson, M.; Ulu, A.; Mukherjee, M.; Yuil-Valdes, A.G.; Thoene, M.; Van Ormer, M.; Slotkowski, R.; Mauch, T.; Anderson-Berry, A.; Hanson, C.K.; et al. Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development. Biomedicines 2023, 11, 171. https://doi.org/ 10.3390/biomedicines11010171

Comments

Open access.

Abstract

Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.