Predicting Personalized Responses to Dietary Fiber Interventions: Opportunities for Modulation of the Gut Microbiome to Improve Health

Authors

Car Reen Kok, University of Nebraska-Lincoln
Devin J. Rose, University of Nebraska-LincolnFollow
Robert Hutkins, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

11-29-2022

Citation

Annu. Rev. Food Sci. Technol. 2023. 14:157–82. https://doi.org/10.1146/annurev-food-060721- 015516

Comments

Open access.

Abstract

Inadequate dietary fiber consumption has become common across industrialized nations, accompanied by changes in gut microbial composition and a dramatic increase in chronic metabolic diseases.The human gut microbiome harbors genes that are required for the digestion of fiber, resulting in the production of end products that mediate gastrointestinal and systemic benefits to the host. Thus, the use of fiber interventions has attracted increasing interest as a strategy to modulate the gut microbiome and improve human health. However, considerable interindividual differences in gut microbial composition have resulted in variable responses toward fiber interventions. This variability has led to observed nonresponder individuals and highlights the need for personalized approaches to effectively redirect the gut ecosystem. In this review, we summarize strategies used to address the responder and nonresponder phenomenon in dietary fiber interventions and propose a targeted approach to identify predictive features based on knowledge of fiber metabolism and machine learning approaches.