Nutrigenomic Functions of PPARs in Obesogenic Environments

Authors

Soonkyu Chung, University of Nebraska-LincolnFollow
Young Jun Kim, Korea University
Soo Jin Yang, Seoul Women’s University
Yunkyoung Lee, Jeju National University
Myoungsook Lee, Sungshin Women's University

Document Type

Article

Date of this Version

2016

Citation

Hindawi Publishing Corporation PPAR Research, Volume 2016, Article ID 4794576, 17 pages

Comments

Copyright © 2016 Soonkyu Chung et al.This is an open access article distributed under the Creative Commons Attribution License

Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments.This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities.