Reply to D. E. Watt, A. S. Alkharam, M. B. Child and M. S. Salikin, “Dose as a Damage Specifier in Radiobiology for Radiation Protection." A Comment on "Dose" (Radiat. Res. 137, 410-413, 1994)

Authors

Robert Katz, University of Nebraska-LincolnFollow

Date of this Version

August 1994

Comments

Published in Radiation Research, Vol. 139, No. 2 (Aug., 1994), pp. 251-253. Copyright © 1994 Radiation Research Society. http://www.radres.org/ECOMradres/timssnet/common/tnt_frontpage.cfm Used by permission.

Abstract

The authors are generous in observing that "the high degree of success achieved by (Katz's δ-ray theory of track structure) in fits to survival curves for heavy ions, and in analysis and prediction of other biological effects is almost legend." We remind them that the model is physical, and has little to do with biology in an explicit way, except that an oversimplified "bean bag" model of a eukaryotic cell is used, in which the bag represents the cell nucleus and the beans represent internal targets. No explicit biologically mechanistic structure or response is inferred. No reference is made to DNA. The model rests on its fit to data rather than on its relationship to a presumed mechanism, however universally that presumption is held.