RADIOSENSITIVITY PARAMETERS FOR LETHAL MUTAGENESIS IN CAENORHABDITIS ELEGANS

Authors

• F. A. Cucinotta, NASA Langley Research Center, Hampton, VAFollow
• J. W. Wilson, NASA Langley Research Center, Hampton, VA
• Robert Katz, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

January 1994

Comments

Published in Radiation Protection Dosimetry Vol. 52, Nos 1-4, pp 25-27 (1991).

Abstract

For the first time track structure theory has been applied to radiobiological effects in a living organism. Data for lethal mutagenesis in Caenorhabditis elegans, obtained after irradiation with nine different types of ions of atomic number 1-57 and gamma rays have yielded radiosensitivity parameters (E₀, σ₀, K, m = 68 Gy, 2.5 x 10^-9 cm², 750, 2) comparable with those found for the transformation of C3HT10 1/2 cells (180 Gy, 1.15 x 10^-10 cm², 750, 2) but remote from those (E₀ and σ₀ = ≈2 Gy, ≈5 x 10^-7 cm²) for mammalian cell survival.