RADIOSENSITIVITY PARAMETERS FOR LETHAL MUTAGENESIS IN CAENORHABDITIS ELEGANS

Authors

F. A. Cucinotta, NASA Langley Research Center, Hampton, VAFollow
J. W. Wilson, NASA Langley Research Center, Hampton, VA
Robert Katz, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

January 1994

Comments

Published in Radiation Protection Dosimetry Vol. 52, Nos 1-4, pp 25-27 (1991).

Abstract

For the first time track structure theory has been applied to radiobiological effects in a living organism. Data for lethal mutagenesis in Caenorhabditis elegans, obtained after irradiation with nine different types of ions of atomic number 1-57 and gamma rays have yielded radiosensitivity parameters (E₀, σ₀, K, m = 68 Gy, 2.5 x 10^-9 cm², 750, 2) comparable with those found for the transformation of C3HT10 1/2 cells (180 Gy, 1.15 x 10^-10 cm², 750, 2) but remote from those (E₀ and σ₀ = ≈2 Gy, ≈5 x 10^-7 cm²) for mammalian cell survival.