Plant Science Innovation, Center for

 

Document Type

Article

Date of this Version

2011

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 50, pp. 43272–43281, December 16, 2011

Comments

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: HopU1 ADP-ribosylates GRP7, suppressing plant immunity.

Results: The HopU1 structure has two novel loops required for GRP7 recognition, and HopU1 ribosylates GRP7 at an arginine in position 49 disrupting its function.

Conclusion: HopU1 targets a conserved arginine in GRP7, disabling its ability to bind immunity-related RNA.

Significance: The mechanistic details of how HopU1 recognizes its substrate reveal how HopU1 contributes to pathogenesis.

Share

COinS