RNA interference: traveling in the cell and gaining functions?

Authors

Heriberto D. Cerutti, University of Nebraska - LincolnFollow

Date of this Version

January 2003

Comments

Published in Trends in Genetics 19:1 (January 2003), pp. 39-46; doi:10.1016/S0168-9525(02)00010-0 Copyright © 2002 Elsevier Science Ltd. Used by permission. http://tigs.trends.com

Abstract

Double-stranded RNA can induce the degradation of homologous RNAs in organisms as diverse as protozoa, animals, plants and fungi, resulting in post-transcriptional gene silencing. But in some species, RNA-mediated processes can also lead to translational repression, DNA methylation, heterochromatin formation or DNA elimination. In some situations, amplification of the “trigger” double-stranded RNA seems to be required for efficient silencing. These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments.