Fluoxetine, Smoking, and History of Major Depression: A Randomized Controlled Trial

Authors

• Bonnie Spring, University of Illinois at Chicago
• Neal Doran, University of Illinois at Chicago
• Sherry Pagoto, University of Illinois at Chicago
• Dennis E. McChargue, University of Nebraska-LincolnFollow
• Jessica Werth Cook, University of Illinois at ChicagoFollow
• Katherine Bailey, University of Illinois at Chicago
• John Crayton, Edward Hines Jr. Veterans Affairs Hospital
• Donald Hedecker, University of Illinois at Chicago

Document Type

Article

Date of this Version

11-1-2007

Comments

Published in Journal of Consulting and Clinical Psychology 2007, Vol. 75. No. 1, 85-94. Copyright 2007. Used by permission.

Abstract

The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.