Neurodevelopmental Outcomes After Cardiac Surgery in Infancy

Authors

J. William Gaynor, The Children’s Hospital of Philadelphia
Christian Stopp, Boston Children’s Hospital
David Wypij, Boston Children’s Hospital
Dean B. Andropoulos, Texas Children’s Hospital
Joseph Atallah, Stollery Children’s Hospital
Andrew M. Atz, Medical University of South Carolina
John Beca, Starship Children’s Hospital
Mary T. Donofrio, Children’s National Medical Center
Kim Duncan, Children’s Hospital and Medical Center
Nancy S. Ghanayem, Medical College of Wisconsin
Caren S. Goldberg, Mott’s Children’s Hospital
Hedwig Hövels-Gürich, University Hospital Aachen
Fukiko Ichida, Toyama University Hospital
Jeffrey P. Jacobs, Johns Hopkins All Children’s Heart Institute
Robert Justo, University of Queensland
Beatrice Latal, University Children’s Hospital Zurich
Jennifer S. Li, Duke University Medical Center
William T. Mahle, Children’s Healthcare of Atlanta
Patrick S. McQuillen, University of California
Shaji C. Menon, Primary Children’s Medical Center
Victoria L. Pemberton, National Heart, Lung, and Blood Institute
Nancy A. Pike, Children’s Hospital Los Angeles
Christian Pizarro, Alfred I. duPont Hospital for Children
Lara S. Shekerdemian, The Royal Children’s Hospital
Anne Synnes, University of British Columbia
Ismee Williams, New York-Presbyterian Morgan Stanley Children’s Hospital of New York
David C. Bellinger, Boston Children’s Hospital
Jane W. Newburger, Boston Children’s Hospital

Date of this Version

4-2015

Citation

Pediatrics Vol. 135 No. 5 May 1, 2015, pp. 816 -825 (doi: 10.1542/peds.2014-3825).

Comments

U.S. government work.

Abstract

BACKGROUND: Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD).

METHODS: We analyzed individual participant data from studies of children evaluated with the Bayley Scales of Infant Development, second edition, after cardiac surgery between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), and the secondary outcome was Mental Development Index (MDI).

RESULTS: Among 1770 subjects from 22 institutions, assessed at age 14.5 +/- 3.7 months, PDIs and MDIs (77.6 +/- 18.8 and 88.2 +/- 16.7, respectively) were lower than normative means (each PCONCLUSIONS: Early neurodevelopmental outcomes for survivors of cardiac surgery in infancy have improved modestly over time, but only after adjustment for innate patient risk factors. As more high-risk CHD infants undergo cardiac surgery and survive, a growing population will require significant societal resources.