Demographic Risk Factors for Severe and Fatal Vivax and Falciparum Malaria Among Hospital Admissions in Northeastern Indonesian Papua

Authors

Mazie J. Barcus, 2061 Winged Foot Court, Reston, VA
Hasan Basri, Family Health InternationalFollow
Helena Picarima, Family Health International, Kota Jayapura, Papua 99920, Indonesia
C. Manyakori, R.S. Persahabatan, Jl. Persahabatan Raya, Rawamangun, Jakarta, Indonesia
Puslitbang Biomedis & Farmasi, Jl. Percetakan Negara No. 29, Jakarta 10560, Indonesia, Puslitbang Biomedis & Farmasi, Jl. Percetakan Negara No. 29, Jakarta 10560, Indonesia
Iqbal Elyazar, Parasitology Department Program, U.S. NAMRU-2, American Embassy Jakarta, Unit 8132, FPO AP 96520-8132Follow
Michael J. Bangs, Public Health and Malaria Control Department, Freeport, Jl. Kertajasa, Kuala Kencana, Papua 99920, Indonesia
Jason D. Maguire, Naval Medical Center Portsmouth, Portsmouth, VAFollow
J. Kevin Baird, Eijkman-Oxford Clinical Research Unit, Eijkman Institute, Jl. Diponegoro No. 69, Jakarta 10430, IndonesiaFollow

Date of this Version

2007

Citation

Am. J. Trop. Med. Hyg., 77(5), 2007, pp. 984–991

Comments

U.S. Government Work

Abstract

Between January 1998 and December 2000, the Jayapura Provincial Public Hospital in northeastern Indonesian New Guinea (Papua) admitted 5,936 patients with a diagnosis of malaria. The microscopic diagnosis at admission was Plasmodium falciparum (3,976, 67%), Plasmodium vivax (1,135, 19%), Plasmodium malariae (8, < 1%), and mixed species infections (817, 14%). Approximately 9% (367) of patients were classified as having severe malaria (277 P. falciparum, 36 P. vivax, 53 mixed infections, and 1 P. malariae) and 88 died (79 P. falciparum/mixed infections and 9 P. vivax). Risk of fatal outcomes among severe malaria patients was indistinguishable between those with falciparum versus vivax malaria (OR=0.89; P=0.771). Compared with non-pregnant women, pregnant women showed no higher risk of severe malaria (P=0.643) or death caused by severe malaria (P=0.748). This study compares admissions per population (based on census data), parasitemia, morbidity, and mortality among children versus adults, pregnant versus non-pregnant women, and urban/suburban versus rural residents.