Authors
Din Syafruddin, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, and Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Michael J. Bangs, Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia
Dian Sidik, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar
Iqbal Elyazar, Eijkman-Oxford Clinical Research Unit, Jakarta, IndonesiaFollow
Puji B.S. Asih, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Krisin Chan, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Siti Nurleila, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia
Christian Nixon, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
Joko Hendarto, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Isra Wahid, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Hasanuddin Ishak, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Claus Bogh, The Sumba Foundation, Bali, Indonesia
John P. Grieco, Department of Preventive Medicine and Biometrics, Uniformed Services, University of the Health Sciences, Bethesda, MD
Nicole L. Achee, Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN
J. Kevin Baird, ALERTAsia FoundationFollow
Date of this Version
2014
Citation
Am. J. Trop. Med. Hyg., 91(6), 2014, pp. 1079-1087
Abstract
A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk of malaria in Indonesia. Following presumptive radical cure for malaria in 180 adult men representing sentinels of new infection in four clusters within two villages, all households were given either metofluthrin or placebo mosquito coils. Weekly blood smear screening and human-landing mosquito catches were done throughout the 6 months intervention. Malaria infections occurred in 61 subjects living in placebo households and 31 subjects living in SR coil households, suggesting a 52% protective effect of SR. Likewise, anopheles indoor human landing rates were 32% lower in homes receiving SR coils. Differences in the malaria attack rate between SR- and placebo-treated homes was significant when not accounting for the effects of clustering. When the analysis was adjusted for intra-cluster correlation, the differences between SR- and placebo-treated homes were not statistically significant. The findings provide evidence of SR public health benefit and support a larger trial statistically powered to detect those effects.
Comments
Copyright © 2014 by The American Society of Tropical Medicine and Hygiene