Neuroimaging of the Philadelphia Neurodevelopmental Cohort

Authors

Theodore D. Satterthwaite, University of PennsylvaniaFollow
Mark A. Elliott, University of Pennsylvania
Kosha Ruparel, University of Pennsylvania
James Loughead, University of Pennsylvania
Karthik Prabhakaran, University of Pennsylvania
Monica E. Calkins, University of Pennsylvania
Ryan Hopson, University of Pennsylvania
Chad Jackson, University of Pennsylvania
Jack Keefe, University of Pennsylvania
Marisa Riley, University of Pennsylvania
Frank D. Mentch, The Children's Hospital of Philadelphia
Patrick Sleiman, The Children's Hospital of Philadelphia
Ragini Verma, University of Pennsylvania
Christos Davatzikos, University of Pennsylvania
Hakon Hakonarson, The Children's Hospital of Philadelphia
Ruben C. Gur, University of Pennsylvania
Raquel E. Gur, University of Pennsylvania

Date of this Version

2014

Citation

NeuroImage 86 (2014) 544–553

Comments

U.S. Government Work

Abstract

The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8–21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.