Public Health Resources
Date of this Version
2015
Citation
The FASEB Journal vol. 29 no. 8 3287-3301 (2015)
Abstract
This study determined if twice-daily consumption
of a nutrient-dense bar intended to fill gaps in
Western diets, without other dietary/lifestyle requirements,
favorably shifted metabolic/anthropometric indicators
of dysregulation in a healthy direction. Three 8-wk
clinical trials in 43 healthy lean and overweight/obese
(OW/OB) adults, who served as their own controls, were
pooled for analysis. In less inflamed OW/OB [highsensitivity
C-reactive protein (hsCRP) <1.5], statistically
significant decreases occurred in weight (-1.1 ± 0.5 kg),
waist circumference (-3.1 ± 1.4 cm), diastolic blood
pressure (-4.1 ± 1.6 mmHg), heart rate [HR;-4.0 ± 1.7
beats per minute (bpm)], triglycerides (272638.2mg/dl),
insulin resistance (homeostatic model of insulin resistance)
(-0.72 ± 0.3), and insulin (-2.8 ± 1.3 mU/L);
an increase in HDL-2b (+303 ± 116 nM) and realignment
of LDL lipid subfractions toward a less atherogenic profile
[decreased small LDL IIIb (-44 ± 23.5 nM), LDL IIIa
(299643.7nM),andincreased largeLDLI (+66±28.0nM)].
In the more inflamed OW/OB (hsCRP >1.5), inflammation
was reduced at 2 wk (20.66 mg/L), and HR at
8 wk (-3.4 ± 1.3 bpm). The large HDL subfraction
(10.5–14.5 nm) increased at 8 wk (+346 ± 126 nM). Metabolic
improvements were also observed in lean participants.
Thus, favorable changes in measures of cardiovascular
health, insulin resistance, inflammation, and obesity were
initiated within 8 wk in the OW/OB by replacing deficiencies
in Western diets without requiring other dietary
or lifestyle modifications; chronic inflammation
blunted most improvements.—McCann, J. C., Shigenaga,
M. K., Mietus-Snyder, M. L., Lal, A., Suh, J. H., Krauss,
R. M., Gildengorin, G. L., Goldrich, A. M., Block, D. S.,
Shenvi, S. V.,McHugh, T. H.,Olson,D. A., Ames, B.N. A
multicomponent nutrient bar promotes weight loss
and improves dyslipidemia and insulin resistance in
the overweight/obese: chronic inflammation blunts
these improvements.
Comments
U.S. Government Work