Current prospects of type II interferon γ signaling & autoimmunity

Authors

Daniel S. Green, National Cancer Institute (NCI)
Howard A. Young, National Cancer InstituteFollow
Julio C. Valencia, National Cancer Institute at FrederickFollow

Date of this Version

8-25-2017

Citation

J. Biol. Chem. (2017) 292(34) 13925–13933

DOI 10.1074/jbc.R116.774745

Comments

This is an Open Access article under the CC BY license.

Abstract

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into IFNγ signaling have provided insight into the general concepts of receptor signaling, receptor internalization, regulation of distinct signaling pathways, and transcriptional regulation. Although IFNγ is the central mediator of the adaptive immune response to pathogens, it has been shown to be involved in several non-infectious physiological processes. This review will provide an introduction into IFNγ signaling biology and the functional roles of IFNγ in the autoimmune response.