Department of Special Education and Communication Disorders

 

ORCID IDs

http://orcid.org/0000-0002-3857-0055

http://orcid.org/0000-0002-5256-0013

http://orcid.org/0000-0003-2578-3155

http://orcid.org/0000-0002-5497-7197

http://orcid.org/0000-0003-4335-3650

http://orcid.org/0000-0001-5018-3659

http://orcid.org/0000-0002-9348-0933

http://orcid.org/0000-0001-7547-2051

Document Type

Article

Date of this Version

1-2-2020

Citation

2020 Author(s)

Comments

NATURE COMMUNICATIONS | (2020)11:63 | https://doi.org/10.1038/s41467-019-13710-4 | www.nature.com/naturecommunications

Abstract

Each vestibular sensory epithelium in the inner ear is divided morphologically and physio- logically into two zones, called the striola and extrastriola in otolith organ maculae, and the central and peripheral zones in semicircular canal cristae. We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)- mediated degradation of retinoic acid (RA). In Cyp26b1 conditional knockout mice, formation of striolar/central zones is compromised, such that they resemble extrastriolar/peripheral zones in multiple features. Mutants have deficient vestibular evoked potential (VsEP) responses to jerk stimuli, head tremor and deficits in balance beam tests that are consistent with abnormal vestibular input, but normal vestibulo-ocular reflexes and apparently normal motor performance during swimming. Thus, degradation of RA during embryogenesis is required for formation of highly specialized regions of the vestibular sensory epithelia with specific functions in detecting head motions.

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