The Impact of Depleting Dietary microRNA in a High-fat Diet

Authors

• Briley Moates, University of Nebraska-LincolnFollow
• Sonia Manca, University of Nebraska-LincolnFollow
• Janos Zempleni, University of Nebraska-LincolnFollow

Date of this Version

4-2016

Document Type

Poster

Citation

UCARE Poster session, University of Nebraska-Lincoln Research Fair, April 2016, Lincoln, NE.

Comments

Copyright © 2016 Briley Moates, Sonia Manca, Janos Zempleni

Abstract

We tested the hypothesis that a highfat diet would increase the difference in body weight between C57BL/6J mice provided dietary microRNA (Exo +) and mice which were fed the same diet depleted of microRNA (Exo-).

• The data demonstrate that depleting miRNAs from a high-fat diet does not impact the difference in body weight between Exo+ and Exo- subjects. • Depleting dietary miRNAs from normal low-fat diets do result in differences in body weight, fat, fecundity, purine metabolism, and gut microbiome.