Novel 16S rRNA Methyltransferase RmtH Produced by Klebsiella pneumoniae Associated with War-Related Trauma

Authors

• Jessica A. O'Hara, University of Pittsburgh - Main Campus
• Patrick McGann, Walter Reed Army Institute of Research
• Erik C. Snesrud, Walter Reed Army Institute of Research
• Robert J. Clifford, Walter Reed Army Institute of Research
• Paige E. Waterman, Walter Reed Army Institute of Research
• Emil P. Lesho, Walter Reed Army Institute of Research
• Yohei Doi, University of Pittsburgh - Main CampusFollow

Document Type

Article

Date of this Version

2013

Citation

Published in Antimicrobial Agents and Chemotherapy (2013) 57(5): 2413-2416. DOI:10.1128/AAC.00266-13

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.