Rapid Communication Rescue of Hantaan virus minigenomes

Authors

• Kirsten Flick, Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health
• Connie S. Schmaljohn, U.S. Army Medical Research Institute for Infectious DiseasesFollow
• Ralf F. Petterson, Ludwig Institute for Cancer Research
• Heinz Feldmann, Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, University of Manitoba
• Ramon Flick, Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, University of ManitobaFollow
• Jay Hooper, U.S. Army Medical Research Institute for Infectious Diseases

Document Type

Article

Date of this Version

2003

Citation

Virology 306 (2003) 219–224

Comments

This article is a U.S. government work, and is not subject to copyright in the United States.

Abstract

Hantavirus infections are a major public health concern worldwide. Their widespread geographical distribution and their ability to produce serious, often fatal, human disease underline the need for a system that allows manipulation of these viruses. We describe here the first successful establishment of a reverse genetics technology for Hantaan virus, the prototype of the genus Hantavirus. The system offers a unique opportunity to study the biology of hantaviruses, the pathogenesis of the diseases, and the efficacy of antiviral and prophylactic measures against hantavirus infections.