U.S. Department of Defense

 

Document Type

Article

Date of this Version

2000

Citation

TRENDS IN MICROBIOLOGY 61 VOL. 8 NO. 2 FEBRUARY 2000

Comments

This article is a U.S. government work, and is not subject to copyright in the United States

Abstract

Hantaviruses include serious human pathogens that are maintained in nature in persistently infected rodents and that can also persistently infect cultured mammalian cells, causing little or no cytopathology. The mechanisms of hantavirus persistence are only beginning to be explored. Recent data point to subtle changes in the viral genome that might result in the differential regulation of replication and lead to persistence.

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