Human health risk assessment database, “the NHSRC toxicity value database”: Supporting the risk assessment process at US EPA's National Homeland Security Research Center

Authors

Chandrika J. Moudgal, U.S. EPAFollow
Kevin Garrahan, U.S. EPA
Eletha Brady-Roberts, U.S. EPA
Naida Gavrelis, Eastern Research Group, Inc.
Michelle Arbogast, Eastern Research Group, Inc.
Sarah Dun, Eastern Research Group, Inc.

Document Type

Article

Date of this Version

2008

Citation

Published in Toxicology and Applied Pharmacology 233 (2008) 25–33. DOI:10.1016/j.taap.2007.12.040

Abstract

The toxicity value database of the United States Environmental Protection Agency's (EPA) National Homeland Security Research Center has been in development since 2004. The toxicity value database includes a compilation of agent property, toxicity, dose–response, and health effects data for 96 agents: 84 chemical and radiological agents and 12 biotoxins. The database is populated with multiple toxicity benchmark values and agent property information from secondary sources, with web links to the secondary sources, where available. A selected set of primary literature citations and associated dose–response data are also included. The toxicity value database offers a powerful means to quickly and efficiently gather pertinent toxicity and dose–response data for a number of agents that are of concern to the nation's security. This database, in conjunction with other tools, will play an important role in understanding human health risks, and will provide a means for risk assessors and managers to make quick and informed decisions on the potential health risks and determine appropriate responses (e.g., cleanup) to agent release. A final, stand alone MS ACESSS working version of the toxicity value database was completed in November, 2007.