Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains

Authors

Juliana Martha Sá, Universidade de Sao Paulo
Takashi Nomura, National Institutes of Health
Joana D'Arc Neves, Centro de Pesquisa em Medicina Tropical
J. Kevin Baird, U.S. Naval Medical Research Unit # 2Follow
Thomas E. Wellems, National Intitutes of Health
Hernando A. del Portillo, Universidade de Sao PauloFollow

Date of this Version

2005

Citation

Published in Experimental Parasitology 109 (2005) 256–259. DOI:10.1016/j.exppara.2004.12.005

Abstract

We describe here the sequence of the Plasmodium vivax mdr1 gene from 10 different isolates differing in chloroquine sensitivity. The deduced amino acid sequence of PvMDR1 shares more than 70% similarity with other malarial MDR proteins and it displays consensus motifs of an ABC family transporter including two transmembrane domains and two ATP binding cassettes. Similarity and dendrogram analyses revealed that sequences could be grouped according to their geographical origin. Within each geographical group however, no correlation was found between chloroquine resistance and specific mutations.