Veterinary and Biomedical Sciences, Department of


Date of this Version



Published in INFECTION AND IMMUNITY, Apr. 1989, p. 1339-1342 Vol. 57, No. 4. Copyright © 1989, American Society for Microbiology. Used by permission.


Gnotobiotic piglets inoculated with Escherichia coli serotype 0157:H7 strains that produced Shiga-like toxin II developed brain lesions similar to those observed in edema disease of swine, including arteriolar necrosis and malacia. Loss of ability to produce Shiga-like toxin II resulted in loss of ability to cause brain lesions.