Nebraska Center for Virology: Faculty Publications
Accessibility Remediation
If you are unable to use this item in its current form due to accessibility barriers, you may request remediation through our remediation request form.
Document Type
Article
Date of this Version
December 2001
Abstract
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein–Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
Comments
Published in Seminars in Cancer Biology 11:6 (December 2001), pp. 445-453; doi10.1006/scbi.2001.0411. Copyright © 2001 Academic Press/Elsevier. Used by permission. http://www.sciencedirect.com/science/journal/1044579X Published online June 26, 2002.