Virology, Nebraska Center for


Date of this Version

December 2001


Published in Seminars in Cancer Biology 11:6 (December 2001), pp. 445-453; doi10.1006/scbi.2001.0411. Copyright © 2001 Academic Press/Elsevier. Used by permission. Published online June 26, 2002.


Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein–Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.

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