Domain I of the 5′ non-translated genomic region in coxsackievirus B3 RNA is not required for productive replication

Authors

L. Jaramillo, University of Nebraska Medical Center
S. Smithee, University of Nebraska Medical Center
S. Tracy, University of Nebraska Medical Center
N. M. Chapman, University of Nebraska Medical Center

Date of this Version

2016

Citation

Virology 496 (2016) 127–130

Comments

Copyright 2016 The Authors.

Abstract

Domain I is a cloverleaf-like secondary structure at the 5′ termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5′ genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.