Nebraska Center for Virology: Faculty Publications

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Document Type

Article

Date of this Version

2016

Citation

Virology 496 (2016) 127–130

Comments

Copyright 2016 The Authors.

Abstract

Domain I is a cloverleaf-like secondary structure at the 5′ termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5′ genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.

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