Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production

Authors

Lilian Flores-Mendoza, Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico
Erika Silva-Campa, Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico
Monica Resendiz, Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico
Fernando A. Osorio, University of Nebraska-LincolnFollow
Jesus Hernandez, Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico

Document Type

Article

Date of this Version

April 2008

Comments

Published in CLINICAL AND VACCINE IMMUNOLOGY, Apr. 2008, p. 720–725 Vol. 15, No. 4 1556-6811 doi:10.1128/CVI.00224-07 Copyright © 2008, American Society for Microbiology. Used by permission.

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.