Virology, Nebraska Center for


Date of this Version

April 2008


Published in CLINICAL AND VACCINE IMMUNOLOGY, Apr. 2008, p. 720–725 Vol. 15, No. 4 1556-6811 doi:10.1128/CVI.00224-07 Copyright © 2008, American Society for Microbiology. Used by permission.


Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

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