Antimicrobial resistance patterns of Campylobacter from feedlot cattle

Authors

• M. D. Englen, USDA-ARS
• R. J. Fedorka-Cray, USDA-ARS
• S. R. Ladely, USDA-ARS
• D. A. Dargatz, USDA-APHIS

Document Type

Article

Date of this Version

2005

Citation

Journal of Applied Microbiology 2005, 99, 285–291 doi:10.1111/j.1365-2672.2005.02609.x

Comments

This article is a U.S. government work, and is not subject to copyright in the United States.

Abstract

Aims: This study examined 448 Campylobacter strains isolated in 1999 and 2000 from US feedlot cattle for resistance to 12 antimicrobials. Methods and Results: Isolates were tested for antimicrobial susceptibility using the E-test method. Approximately 60% (n = 267) were resistant to one or more antimicrobials, and 19·6% (n = 88) were resistant to two or more antimicrobials. Of the Campylobacter jejuni isolates, 49·1% (n = 187) were resistant to tetracycline, 10·2% (n = 39) were resistant to nalidixic acid, 8·4% were resistant to trimethoprim/sulfamethoxazole, and 1·8% (n = 7) were resistant to ciprofloxacin. Resistance to any of the other eight antimicrobials was 1·3% or less, but 14·4% (n = 55) were resistant to two or more antimicrobials. In the Campylobacter coli group, 65·7% (n = 44) were resistant to tetracycline, 52·2% (n = 35) were resistant to trimethoprim/sulfamethoxazole, 22·4% (n = 15) were resistant to nalidixic acid, and 9·0% (n = 6) were resistant to ciprofloxacin. Resistance to any of the remaining eight antimicrobials was 3·0% or less, although 49·3% (n = 33) were resistant to two or more antimicrobials. Conclusions: Although antimicrobials are widely used in US feedlot cattle production, our results demonstrate generally low levels of resistance to a broad range of commonly used antimicrobials relative to other recent studies. Significance and Impact of the Study: Resistance data on Campylobacter isolated from this major US livestock commodity is lacking. This overview enhances current knowledge and provides a basis for further studies.