Additional evidence showing an additive effect of glucocorticoid receptor polymorphisms on anxietytype behavior, stress response, and body weight in a population of mice with low heat loss background
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We conclude that the mice with GR8q/8q have greater stress responsiveness than the GR16q/16q mice independent of line. The GR-16q allelic effect is much weaker in the SH line while both polymorphic forms of GRs exhibited a strong additive effect on behavior under either control or stressed conditions, as well as on body weight, in the SL line of mice. However, this GR polymorphism does not appear to be linked to heat loss. Additional experiments are underway, including creating SH-SL line-cross combination of GR genotypes, to further confirm this conclusion.