Additional evidence showing an additive effect of glucocorticoid receptor polymorphisms on anxietytype behavior, stress response, and body weight in a population of mice with low heat loss background

Authors

You Zhou, University of Nebraska-LincolnFollow
Sasha Zheng, University of Nebraska-Lincoln
Whitney Sprout, University of Nebraska-Lincoln
Jennifer McDonald, University of Nebraska-Lincoln
Merlyn K. Nielsen, University of Nebraska-LincolnFollow

Date of this Version

1-2008

Comments

Published in The FASEB Journal Vol. 22 January 2008, pp. 6-8. Copyright © 2008 by the Federation of American Societies for Experimental Biology.

The Federation of American Societies for Experimental Biology does not permit deposit in an institutional repository, so the button at right links to an open-access PDF version on the FASEB Journal site.

Abstract

We conclude that the mice with GR^8q/8q have greater stress responsiveness than the GR^16q/16q mice independent of line. The GR-16q allelic effect is much weaker in the SH line while both polymorphic forms of GRs exhibited a strong additive effect on behavior under either control or stressed conditions, as well as on body weight, in the SL line of mice. However, this GR polymorphism does not appear to be linked to heat loss. Additional experiments are underway, including creating SH-SL line-cross combination of GR genotypes, to further confirm this conclusion.