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Mice were fed a mixture of conjugated linoleic acid isomers (CLA) for nine weeks and then underwent an insulin tolerance test. CLA was then removed from the diet and a second insulin tolerance test was conducted following five weeks of recovery. CLA consumption impaired glucose response to insulin. When CLA was removed from the diet, insulin sensitivity of a low heat-loss genetic mouse line returned to normal. However, mice of a high heat-loss line remained insulin resistant for at least 32 days.