Effect of Conjugated Linoleic Acid on Insulin Sensitivity

Authors

• Kim Hargrave, University of Nebraska-Lincoln
• Jess L. Miner, University of Nebraska-LincolnFollow

Date of this Version

January 2002

Comments

Published in 2002 Nebraska Beef Cattle Report. Copyright © 2001 The Board of Regents of the University of Nebraska.

Abstract

Mice were fed a mixture of conjugated linoleic acid isomers (CLA) for nine weeks and then underwent an insulin tolerance test. CLA was then removed from the diet and a second insulin tolerance test was conducted following five weeks of recovery. CLA consumption impaired glucose response to insulin. When CLA was removed from the diet, insulin sensitivity of a low heat-loss genetic mouse line returned to normal. However, mice of a high heat-loss line remained insulin resistant for at least 32 days.