Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 40, pp. 27794–27806, October 3, 2014
Background: Proline is an important amino acid for stress resistance in different organisms.
Results: Depletion of proline biosynthesis disrupts redox homeostasis and increases sensitivity to endoplasmic reticulum (ER) stress in yeast.
Conclusion: Proline biosynthesis is critical for maintaining the intracellular redox environment and the UPR during ER stress.
Significance: Proline metabolism is shown to have an important role in ER stress tolerance that was previously unknown.