Biochemistry, Department of
Date of this Version
2014
Citation
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 40, pp. 27794–27806, October 3, 2014
Abstract
Background: Proline is an important amino acid for stress resistance in different organisms.
Results: Depletion of proline biosynthesis disrupts redox homeostasis and increases sensitivity to endoplasmic reticulum (ER) stress in yeast.
Conclusion: Proline biosynthesis is critical for maintaining the intracellular redox environment and the UPR during ER stress.
Significance: Proline metabolism is shown to have an important role in ER stress tolerance that was previously unknown.
Included in
Biochemistry Commons, Biotechnology Commons, Other Biochemistry, Biophysics, and Structural Biology Commons
Comments
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.