Biochemistry, Department of

 

Document Type

Article

Date of this Version

2014

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 40, pp. 27794–27806, October 3, 2014

Comments

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: Proline is an important amino acid for stress resistance in different organisms.

Results: Depletion of proline biosynthesis disrupts redox homeostasis and increases sensitivity to endoplasmic reticulum (ER) stress in yeast.

Conclusion: Proline biosynthesis is critical for maintaining the intracellular redox environment and the UPR during ER stress.

Significance: Proline metabolism is shown to have an important role in ER stress tolerance that was previously unknown.

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