Professor
School of Biological Sciences
University of Nebraska-Lincoln

Larry Harshman investigates the genetic, physiological and other biological factors that underlie extended longevity of Drosophila melanogaster. The aging research is supported by NIH. His laboratory also studies stress resistance and aspects of reproduction of D. melanogaster.

Follow

2016

PDF

Evidence for the fixation of gene duplications by positive selection in Drosophila, Margarida Cardoso-Moreira, J. Roman Arguello, Srikanth Gottipati, Lawrence G. Harshman, Jennifer K. Grenier, and Andrew G. Clark

2013

PDF

Heritability and Inter-Population Differences in Lipid Profiles of Drosophila melanogaster, Cornelia J. F. Scheitz, Yu Guo, Angela M. Early, Lawrence G. Harshman, and Andrew G. Clark

2012

PDF

Evolution of starvation resistance in Drosophila melanogaster: Measurement of direct and correlated responses to artificial selection, Tiffany E. Schwasinger-Schmidt, Stephen D. Kachman, and Lawrence G. Harshman

2011

PDF

Increased transsulfuration mediates longevity and dietary restriction in Drosophila, Hadise Kabil, Omer Kabil, Ruma Banerjee, Lawrence G. Harshman, and Scott D. Pletcher

2010

PDF

Bioassays of Compounds with Potential Juvenoid Activity on Drosophila melanogaster: Juvenile Hormone III, Bisepoxide Juvenile Hormone III, and Methyl Farnesoates, Lawrence G. Harshman, Ki-Duck Song, Josephina Casas, A. Schuurmans, Eichii Kuwano, Stephen D. Kachman, Lynn M. Riddiford, and Bruce D. Hammock

2009

PDF

Natural Genetic Variation in Transcriptome Reflects Network Structure Inferred with Major Effect Mutations: Insulin/TOR and Associated Phenotypes in Drosophila melanogaster, Sergey Nuzhdin, Jennifer A. Brisson, Andrew Pickering, Marta Wayne, Lawrence G. Harshman, and Lauren McIntyre

PDF

Natural Genetic Variation in Transcriptome Reflects Network Structure Inferred with Major Effect Mutations: Insulin/TOR and Associated Phenotypes in Drosophila melanogaster, Sergey V. Nuzhdin, Jennifer A. Brisson, Andrew Pickering, Marta L. Wayne, Lawrence G. Harshman, and Lauren M. McIntyre

PDF

Transcriptional Profiling of the Sperm Storage Organs of Drosophila melanogaster, Adrianne M. Prokupek, Stephen D. Kachman, Istvan Ladunga, and Lawrence G. Harshman

PDF

Overexpression of Methionine-R-Sulfoxide Reductases Has No Influence on Fruit Fly Aging, Valentina A. Shchedrina, Gerd Vorbrüggen, Byung Cheon Lee, Hwa-Young Kim, Hadise Kabil, Lawrence G. Harshman, and Vadim N. Gladyshev

2008

PDF

Longevity-Fertility Trade-offs in the Tephritid Fruit Fly, Anastrepha ludens, across Dietary-restriction Gradients, James R. Carey, Lawrence G. Harshman, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, and Zhen Zhang

PDF

An Evolutionary Expressed Sequence Tag Analysis of Drosophila Spermatheca Genes, Adrianne Prokupek, Federico G. Hoffmann, Seong-il Eyun, Etsuko Moriyama, Min Zhou, and Lawrence G. Harshman

2007

PDF

Jhe in Gryllus assimilis: Cloning, sequence-activity associations and phylogeny, E. J. Crone, Anthony J. Zera, A. Anand, J. G. Oakeshott, T. D. Sutherland, R. J. Russell, Lawrence G. Harshman, Federico G. Hoffmann, and C. Claudianos

PDF

The cost of reproduction: the devil in the details, Lawrence G. Harshman and Anthony J. Zera

PDF

Genome-Enabled Hitchhiking Mapping Identifies QTLs for Stress Resistance in Natural Drosophila, Sergey V. Nuzhdin, Lawrence G. Harshman, M. Zhou, and K. Harmon

PDF

Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster, Marta Wayne, Marina Telonis-Scott, Lisa Bono, Lawrence G. Harshman, Artyom Kopp, Sergey V. Nuzhdin, and Lauren McIntyre

PDF

Evolutionary Endocrinology: The Developing Synthesis between Endocrinology and Evolutionary Genetics, Anthony J. Zera, Lawrence G. Harshman, and Tony D. Williams

2006

PDF

Superoxide Dismutase Activities in Long-Lived Drosophila melanogaster Females: chico1 Genotypes and Dietary Dilution, Hadise Kabil, Linda Partridge, and Lawrence G. Harshman

PDF

Sex-Specific Expression of Alternative Transcripts in Drosophila, Lauren McIntyre, Lisa Bono, Anne Genissel, Rick Westerman, Damion Junk, Marina Telonis-Scott, Lawrence G. Harshman, Marta Wayne, Artyom Kopp, and Sergey V. Nuzhdin

PDF

A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival, Yue Wang, David Pot, Stephen D. Kachman, Sergey V. Nuzhdin, and Lawrence G. Harshman

PDF

Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production, Marta L. Wayne, Usha Soundararajan, and Lawrence G. Harshman

2005

PDF

Biodemography of a long-lived tephritid: Reproduction and longevity in a large cohort of female Mexican fruit flies, Anastrepha ludens, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Damla Senturke, and Lawrence G. Harshman

PDF

Stochastic dietary restriction using a Markov-chain feeding protocol elicits complex, life history response in medflies, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Ying Zhang, and Lawrence G. Harshman

PDF

The Symmetry of Longevity, Lawrence G. Harshman, Hans-Georg Müller, Xueli Liu, Yue Wang, and James R. Carey

PDF

Insulin Signaling Is Necessary for Vitellogenesis in Drosophila melanogaster Independent of the Roles of Juvenile Hormone and Ecdysteroids: Female Sterility of the chico1 Insulin Signaling Mutation Is Autonomous to the Ovary, David S. Richard, Robert Rybczynski, Thomas G. Wilson, Yue Wang, Marta L. Wayne, You Zhou, Linda Partridge, and Lawrence G. Harshman

PDF

Quantitative Trait Loci for Lipid Content in Drosophila melanogaster, Mei-Hui Wang, Lawrence G. Harshman, and Sergey V. Nuzhdin

2004

PDF

Biotin Deficiency Decreases Life Span and Fertility but Increases Stress Resistance in Drosophila melanogaster, Anette Landenberger, Hadise Kabil, Lawrence G. Harshman, and Janos Zempleni

PDF

Environment-Dependent Survival of Drosophila melanogaster: A Quantitative Genetic Analysis, Mei-Hui Wang, Oleg Lazebny, Lawrence G. Harshman, and Sergey V. Nuzhdin

2003

PDF

Life Span Extension of Drosophila melanogaster: Genetic and Population Studies, Lawrence G. Harshman

2002

PDF

Food Pulses Increase Longevity and Induce Cyclical Egg Production in Mediterranean Fruit Flies, James R. Carey, Pablo Liedo, Lawrence G. Harshman, X. Liu, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang

PDF

A Mortality Cost of Virginity at Older Ages in Female Mediterranean Fruit Flies, James R. Carey, Pablo Liedo, Lawrence G. Harshman, Ying Zhang, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang

PDF

Life History Response of Mediterranean Fruit Flies to Dietary Restriction, James R. Carey, Pablo Liedo, Lawrence G. Harshman, Ying Zhang, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang

PDF

Purification and Characterization of Hemolymph Juvenile Hormone Esterase from the Cricket, Gryllus assimilis, Anthony J. Zera, Travis Sanger, Jeremiah Hanes, and Lawrence G. Harshman

2001

PDF

Female Sensitivity to Diet and Irradiation Treatments Underlies Sex-Mortality Differentials in the Mediterranean Fruit Fly, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Brad Love, Lawrence G. Harshman, and Linda Partridge

PDF

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein, David Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo Stocker, Ernest Hafen, Sally Leevers, and Linda Partridge

PDF

A Cost of Reproduction in Drosophila melanogaster: Stress Susceptibility, Adam B. Salmon, David B. Marx, and Lawrence G. Harshman

PDF

The Physiology of Life History Trade-Offs in Animals, Anthony J. Zera and Lawrence G. Harshman

2000

PDF

Oxidative Stress Resistance: A Robust Correlated Response to Selection in Extended Longevity Lines of Drosophila melanogaster?, Lawrence G. Harshman and Beth A. Haberer

PDF

"An Evolutionary No Man’s Land" and "Reply from L. G. Harshman and A. A. Hoffmann", Margarida Matos, André Levy, Henrique Teotónio, Michael R. Rose, Lawrence G. Harshman, and Ary A. Hoffmann

1999

PDF

Ecdysteroid Titers in Mated and Unmated Drosophila melanogaster Females, Lawrence G. Harshman, Anne M. Loeb, and Beth A. Johnson

1998

PDF

Differential Gene Expression in Insects: Transcriptional Control, Lawrence G. Harshman and Anthony A. James

1990

PDF

PYOVERDINE PRODUCTION BY PSEUDOMONAS AERUGINOSA EXPOSED TO METALS OR AN OXIDATIVE STRESS AGENT, Kim-Hien Thi Dao, Katherine E. Hamer, Christine L. Clark, and Lawrence G. Harshman

1988

PDF

Environmental Effects on Remating in Drosophila melanogaster, Lawrence G. Harshman, Ary A. Hoffman, and Timothy Prout

1985

PDF

Survivorship and Growth of Sexually and Asexually Derived Larvae of Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma

PDF

The Origin and Distribution of Clonal Diversity in Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma

PDF

Variation in Population Sex Ratio and Mating Success of Asexual Lineages of Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma

PDF

Male Effects on Fecundity in Drosophila melanogaster, Ary A. Hoffman and Lawrence G. Harshman

1980

PDF

Conservation and Variation of Nucleotide Sequences in Escherichia coli Strains Isolated from Nature, Lawrence G. Harshman and Monica Riley