A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival

Authors

Yue Wang, University of Nebraska–Lincoln
David Pot, CIRAD, UMR PIA 1096, Avenue Agropolis
Stephen D. Kachman, University of Nebraska-LincolnFollow
Sergey V. Nuzhdin, University of California, DavisFollow
Lawrence G. Harshman, University of Nebraska - LincolnFollow

ORCID IDs

Stephen D. Kachman

Date of this Version

2006

Document Type

Article

Citation

Journal of Heredity 97:4 (2006), pp. 355–366; doi: 10.1093/jhered/esl009

Comments

© 2006 American Genetic Association. Used by permission.

Abstract

Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of re-combinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density spe-cific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg produc-tion and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.