School of Biological Sciences
University of Nebraska-Lincoln
Larry Harshman investigates the genetic, physiological and other biological factors that underlie extended longevity of Drosophila melanogaster. The aging research is supported by the United States National Institutes of Health. Those in his laboratory also studied stress resistance and aspects of reproduction of D. melanogaster.
2016
Evidence for the fixation of gene duplications by positive selection in Drosophila, Margarida Cardoso-Moreira, J. Roman Arguello, Srikanth Gottipati, Lawrence G. Harshman, Jennifer K. Grenier, and Andrew G. Clark
2014
Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status, Byung Cheon Lee, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V. Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G. Harshman, and Vadim N. Gladyshev
2013
Heritability and Inter-Population Differences in Lipid Profiles of Drosophila melanogaster, Cornelia J. F. Scheitz, Yu Guo, Angela M. Early, Lawrence G. Harshman, and Andrew G. Clark
2012
Evolution of starvation resistance in Drosophila melanogaster: Measurement of direct and correlated responses to artificial selection, Tiffany E. Schwasinger-Schmidt, Stephen D. Kachman, and Lawrence G. Harshman
2011
Increased transsulfuration mediates longevity and dietary restriction in Drosophila, Hadise Kabil, Omer Kabil, Ruma Banerjee, Lawrence G. Harshman, and Scott D. Pletcher
2010
Bioassays of Compounds with Potential Juvenoid Activity on Drosophila melanogaster: Juvenile Hormone III, Bisepoxide Juvenile Hormone III, and Methyl Farnesoates, Lawrence G. Harshman, Ki-Duck Song, Josephina Casas, A. Schuurmans, Eichii Kuwano, Stephen D. Kachman, Lynn M. Riddiford, and Bruce D. Hammock
2009
Natural Genetic Variation in Transcriptome Reflects Network Structure Inferred with Major Effect Mutations: Insulin/TOR and Associated Phenotypes in Drosophila melanogaster, Sergey V. Nuzhdin, Jennifer A. Brisson, Andrew Pickering, Marta L. Wayne, Lawrence G. Harshman, and Lauren M. McIntyre
Transcriptional Profiling of the Sperm Storage Organs of Drosophila melanogaster, Adrianne M. Prokupek, Stephen D. Kachman, Istvan Ladunga, and Lawrence G. Harshman
Overexpression of Methionine-R-Sulfoxide Reductases Has No Influence on Fruit Fly Aging, Valentina A. Shchedrina, Gerd Vorbrüggen, Byung Cheon Lee, Hwa-Young Kim, Hadise Kabil, Lawrence G. Harshman, and Vadim N. Gladyshev
2008
Longevity-Fertility Trade-offs in the Tephritid Fruit Fly, Anastrepha ludens, across Dietary-restriction Gradients, James R. Carey, Lawrence G. Harshman, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, and Zhen Zhang
An Evolutionary Expressed Sequence Tag Analysis of Drosophila Spermatheca Genes, Adrianne Prokupek, Federico G. Hoffmann, Seong-il Eyun, Etsuko N. Moriyama, Min Zhou, and Lawrence G. Harshman
2007
Jhe in Gryllus assimilis: Cloning, sequence-activity associations and phylogeny, E. J. Crone, Anthony J. Zera, A. Anand, J. G. Oakeshott, T. D. Sutherland, R. J. Russell, Lawrence G. Harshman, Federico G. Hoffmann, and C. Claudianos
The cost of reproduction: the devil in the details, Lawrence G. Harshman and Anthony J. Zera
Genome-Enabled Hitchhiking Mapping Identifies QTLs for Stress Resistance in Natural Drosophila, Sergey V. Nuzhdin, Lawrence G. Harshman, M. Zhou, and K. Harmon
Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster, Marta Wayne, Marina Telonis-Scott, Lisa Bono, Lawrence G. Harshman, Artyom Kopp, Sergey V. Nuzhdin, and Lauren McIntyre
Evolutionary Endocrinology: The Developing Synthesis between Endocrinology and Evolutionary Genetics, Anthony J. Zera, Lawrence G. Harshman, and Tony D. Williams
2006
Superoxide Dismutase Activities in Long-Lived Drosophila melanogaster Females: chico1 Genotypes and Dietary Dilution, Hadise Kabil, Linda Partridge, and Lawrence G. Harshman
Sex-Specific Expression of Alternative Transcripts in Drosophila, Lauren McIntyre, Lisa Bono, Anne Genissel, Rick Westerman, Damion Junk, Marina Telonis-Scott, Lawrence G. Harshman, Marta Wayne, Artyom Kopp, and Sergey V. Nuzhdin
A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival, Yue Wang, David Pot, Stephen D. Kachman, Sergey V. Nuzhdin, and Lawrence G. Harshman
Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production, Marta L. Wayne, Usha Soundararajan, and Lawrence G. Harshman
2005
Biodemography of a long-lived tephritid: Reproduction and longevity in a large cohort of female Mexican fruit flies, Anastrepha ludens, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Damla Senturke, and Lawrence G. Harshman
Stochastic dietary restriction using a Markov-chain feeding protocol elicits complex, life history response in medflies, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Ying Zhang, and Lawrence G. Harshman
The Symmetry of Longevity, Lawrence G. Harshman, Hans-Georg Müller, Xueli Liu, Yue Wang, and James R. Carey
Insulin Signaling Is Necessary for Vitellogenesis in Drosophila melanogaster Independent of the Roles of Juvenile Hormone and Ecdysteroids: Female Sterility of the chico1 Insulin Signaling Mutation Is Autonomous to the Ovary, David S. Richard, Robert Rybczynski, Thomas G. Wilson, Yue Wang, Marta L. Wayne, You Zhou, Linda Partridge, and Lawrence G. Harshman
Quantitative Trait Loci for Lipid Content in Drosophila melanogaster, Mei-Hui Wang, Lawrence G. Harshman, and Sergey V. Nuzhdin
2004
Biotin Deficiency Decreases Life Span and Fertility but Increases Stress Resistance in Drosophila melanogaster, Anette Landenberger, Hadise Kabil, Lawrence G. Harshman, and Janos Zempleni
Environment-Dependent Survival of Drosophila melanogaster: A Quantitative Genetic Analysis, Mei-Hui Wang, Oleg Lazebny, Lawrence G. Harshman, and Sergey V. Nuzhdin
2003
Life Span Extension of Drosophila melanogaster: Genetic and Population Studies, Lawrence G. Harshman
2002
Food Pulses Increase Longevity and Induce Cyclical Egg Production in Mediterranean Fruit Flies, James R. Carey, Pablo Liedo, Lawrence G. Harshman, X. Liu, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang
A Mortality Cost of Virginity at Older Ages in Female Mediterranean Fruit Flies, James R. Carey, Pablo Liedo, Lawrence G. Harshman, Ying Zhang, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang
Life History Response of Mediterranean Fruit Flies to Dietary Restriction, James R. Carey, Pablo Liedo, Lawrence G. Harshman, Ying Zhang, Hans-Georg Müller, Linda Partridge, and Jane-Ling Wang
Purification and Characterization of Hemolymph Juvenile Hormone Esterase from the Cricket, Gryllus assimilis, Anthony J. Zera, Travis Sanger, Jeremiah Hanes, and Lawrence G. Harshman
2001
Female Sensitivity to Diet and Irradiation Treatments Underlies Sex-Mortality Differentials in the Mediterranean Fruit Fly, James R. Carey, Pablo Liedo, Hans-Georg Müller, Jane-Ling Wang, Brad Love, Lawrence G. Harshman, and Linda Partridge
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein, David Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo Stocker, Ernest Hafen, Sally Leevers, and Linda Partridge
A Cost of Reproduction in Drosophila melanogaster: Stress Susceptibility, Adam B. Salmon, David B. Marx, and Lawrence G. Harshman
The Physiology of Life History Trade-Offs in Animals, Anthony J. Zera and Lawrence G. Harshman
2000
Oxidative Stress Resistance: A Robust Correlated Response to Selection in Extended Longevity Lines of Drosophila melanogaster?, Lawrence G. Harshman and Beth A. Haberer
"An Evolutionary No Man’s Land" and "Reply from L. G. Harshman and A. A. Hoffmann", Margarida Matos, André Levy, Henrique Teotónio, Michael R. Rose, Lawrence G. Harshman, and Ary A. Hoffmann
1999
Ecdysteroid Titers in Mated and Unmated Drosophila melanogaster Females, Lawrence G. Harshman, Anne M. Loeb, and Beth A. Johnson
1998
Differential Gene Expression in Insects: Transcriptional Control, Lawrence G. Harshman and Anthony A. James
1990
PYOVERDINE PRODUCTION BY PSEUDOMONAS AERUGINOSA EXPOSED TO METALS OR AN OXIDATIVE STRESS AGENT, Kim-Hien Thi Dao, Katherine E. Hamer, Christine L. Clark, and Lawrence G. Harshman
1988
Environmental Effects on Remating in Drosophila melanogaster, Lawrence G. Harshman, Ary A. Hoffman, and Timothy Prout
1985
Survivorship and Growth of Sexually and Asexually Derived Larvae of Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma
The Origin and Distribution of Clonal Diversity in Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma
Variation in Population Sex Ratio and Mating Success of Asexual Lineages of Alsophila pometaria (Lepidoptera: Geometridae), Lawrence G. Harshman and Douglas J. Futuyma
Male Effects on Fecundity in Drosophila melanogaster, Ary A. Hoffman and Lawrence G. Harshman
1980
Conservation and Variation of Nucleotide Sequences in Escherichia coli Strains Isolated from Nature, Lawrence G. Harshman and Monica Riley