Qingsheng Li
Associate Professor
School of Biological Sciences and Nebraska Center for Virology
University of Nebraska-Lincoln

Dr. Li's research is focused on studying HIV-1 pathogenesis, transmission and prevention using single cell in situ analyses and in vivo SIV-rhesus macaque and humanized-BLT (bone marrow liver and thymus) mouse models of HIV-1 infection. He has published extensively on HIV/SIV transmission, pathogenesis and prevention, including one paper in Science and two papers in Nature as the leading author.

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2014

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Serial Cervicovaginal Exposures with Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated with Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques, Shaheed A. Abdulhaqq, Melween I. Martinez, Guobin Kang, Andrea S. Foulkes, Idia V. Rodriguez, Stephanie M. Nichols, Meredith Hunter, Carlos A. Sariol, Lynnette A. Ruiz, Brian N. Ross, Xiangfan Yin, David W. Speicher, Ashley T. Haase, Preston A. Marx, Qingsheng Li, Edmundo N. Kraiselburd, and Luis J. Montaner

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The mucosal expression pattern of interferon-ε in rhesus macaques, Andrew Demers, Guobin Kang, Fangrui Ma, Wuxun Lu, Zhe Yuan, Yue Li, Mark Lewis, Edmundo N. Kraiselburd, Luis Montaner, and Qingsheng Li

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Presence of CD8+ T Cells in the Ectocervical Mucosa Correlates with Genital Viral Shedding in HIV-Infected Women despite a Low Prevalence of HIV RNA–Expressing Cells in the Tissue, Anna Gibbs, Taha Hirbod, Qingsheng Li, Karin Bohman, Terry B. Ball, Francis A. Plummer, Rupert Kaul, Joshua Kimani, Kristina Broliden, and Annelie Tjernlund

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Direct Staining with Major Histocompatibility Complex Class II Dextramers Permits Detection of Antigen- Specific, Autoreactive CD4 T Cells In Situ, Chandirasegaran Massilamany, Arunakumar Gangaplara, Ting Jia, Christian Elowsky, Guobin Kang, Jean-Jack Riethoven, Qingsheng Li, You Zhou, and Jay Reddy

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Humanized-BLT mouse model of Kaposi’s sarcoma-associated herpesvirus infection, Lin-Xu Wang, Guobin Kang, Pankaj Kumar, Wuxun Lu, Yue Li, You Zhou, Qingsheng Li, and Charles Wood

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Construction of a Live-Attenuated HIV-1 Vaccine through Genetic Code Expansion, Nanxi Wang, Yue Li, Wei Niu, Ming Sun, Ronald Cerny, Qingsheng Li, and Jiantao Guo

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Early hypercytokinemia is associated with interferoninduced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection, Zhongfang Wang, Anli Zhang, Yanmin Wan, Xinian Liu, Chao Qiu, Xiuhong Xi, Yanqin Ren, Jing Wang, Yuan Dong, Meijuan Bao, Liangzhu Li, Mingzhe Zhou, Songhua Yuan, Jun Sun, Zhaoqin Zhu, Liang Chen, Qingsheng Li, Zhiyong Zhang, Xiaoyan Zhang, Shuihua Lu, Peter C. Doherty, Katherine Kedzierska, and Jianqing Xu

2012

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Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route, L. Jean Patterson, Seraphin Kuate, Mara Daltabuit-Test, Qingsheng Li, Peng Xiao, Katherine McKinnon, Janet DiPasquale, Anthony Cristillo, David Venzon, Ashley Haase, and Marjorie Robert-Guroff

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SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa, R. Keith Reeves, Tristan I. Evans, Jacqueline Gillis, Fay E. Wong, Guobin Kang, Qingsheng Li, and R. Paul Johnson

2011

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Morphine potentiates neuropathogenesis of SIV infection in rhesus macaques, Sirosh M. Bokhari, Ramakrishna Hedge, Shannon Callen, Honghong Yao, Istvan Adany, Qingsheng Li, Zhuang Li, David Pinson, Hung-Wen Yeh, Paul D. Cheney, and Shilpa Buch

2010

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AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4, Anapatricia Garcίa, Nagadenahalli B. Siddappa, Qingsheng Li, Ashley T. Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A. Fountain, François Villinger, Francis J. Novembre, James G. Else, W. Evan Secor, and Ruth M. Ruprecht

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Challenges and counter challenges in HIV/AIDS, Qingsheng Li and Charles Wood

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Host Genes Associated with HIV-1 Replication in Lymphatic Tissue, Anthony J. Smith, Qingsheng Li, Stephen W. Wietgrefe, Timothy W. Schacker, Cavan S. Reilly, and Ashley T. Haase

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Differences in HIV Burden and Immune Activation within the Gut of HIV-Positive Patients Receiving Suppressive Antiretroviral Therapy, Steven A. Yukl, Sara Gianella, Elizabeth Sinclair, Lorrie Epling, Qingsheng Li, Lijie Duan, Alex L.M. Choi, Valerie Girling, Terence Ho, Peilin Li, Katsuya Fujimoto, Harry Lampiris, C. Bradley Hare, Mark Pandori, Ashley T. Haase, Huldrych F. Günthard, Marek Fischer, Amandeep K. Shergill, Kenneth McQuaid, Diane V. Havlir, and Joseph K. Wong

2009

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Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys, Steven E. Bosinger, Qingsheng Li, Shari N. Gordon, Nichole R. Klatt, Lijie Duan, Luoling Xu, Nicholas Francella, Abubaker Sidahmed, Anthony J. Smith, Elizabeth M. Cramer, Ming Zeng, David Masopust, John V. Carlis, Longsi Ran, Thomas H. Vanderford, Mirko Paiardini, R. Benjamin Isett, Don A. Baldwin, James G. Else, Silvija I. Staprans, Guido Silvestri, Ashley T. Hasse, and David J. Kelvin

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Glycerol monolaurate prevents mucosal SIV transmission, Qingsheng Li, Jacob D. Estes, Patrick M. Schlievert, Lijie Duan, Amanda J. Brosnahan, Peter J. Southern, Cavan S. Reilly, Marnie L. Peterson, Nancy Schultz-Darken, Kevin G. Brunner, Karla R. Nephew, Stefan Pambuccian, Jeffrey D. Lifson, John V. Carlis, and Ashley T. Haase

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Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection, Qingsheng Li, Pamela J. Skinner, Sang-Jun Ha, Lijie Duan, Teresa L. Mattila, Aaron Hage, Cara White, Daniel L. Barber, Leigh O'Mara, Peter J. Southern, Cavan S. Reilly, John V. Carlis, Christopher J. Miller, Rafi Ahmed, and Ashley T. Haase

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Microarray Analysis of Lymphatic Tissue Reveals Stage- Specific, Gene Expression Signatures in HIV-1 Infection1, Qingsheng Li, Anthony J. Smith, Timothy W. Schacker, John V. Carlis, Lijie Duan, Cavan S. Reilly, and Ashley T. Haase

2008

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Simian Immunodeficiency Virus–Induced Intestinal Cell Apoptosis Is the Underlying Mechanism of the Regenerative Enteropathy of Early Infection, Qingsheng Li, Jacob D. Estes, Lijie Duan, Jose Jessurun, Stefan Pambuccian, Colleen Forster, Stephen Wietgrefe, Mary Zupancic, Timothy Schacker, Cavan Reilly, John V. Carlis, and Ashley T. Haase

2006

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Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection, Jacob D. Estes, Qingsheng Li, Matthew R. Reynolds, Stephen W. Wietgrefe, Lijie Duan, Timothy Schacker, Louis J. Picker, David I. Watkins, Jeffrey D. Lifson, Cavan Reilly, John V. Carlis, and Ashley T. Haase

2005

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Potential Roles of Follicular Dendritic Cell–Associated Osteopontin in Lymphoid Follicle Pathology and Repair and in B Cell Regulation in HIV-1 and SIV Infection, Qingsheng Li, Jeffrey D. Lifson, Lijie Duan, Timothy Schacker, Cavan Reilly, John V. Carlis, Jacob D. Estes, and Ashley T. Haase

2004

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Roles of substrate availability and infection of resting and activated CD4+T cells in transmission and acute simian immunodeficiency virus infection, Zhi-Qiang Zhang, Stephen W. Wietgrefe, Qingsheng Li, Marta Dykhuizen Shore, Lijie Duan, Cavan Reilly, Jeffrey D. Lifson, and Ashley T. Haase

2000

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Quantitative Image Analysis of Simian Immunodeficiency Virus Replication in Macrophages Coinfected with Mycobacterium avium Complex, Qingsheng Li, Keith G. Mansfield, Andrew Lackner, and Ashley T. Haase