Improved Arene Fluorination Methodology for I(III) Salts

Authors

Bijia Wang, University of Nebraska-Lincoln
Linlin Qin, University of Nebraska-Lincoln
Kiel D. Neumann, University of Nebraska-Lincoln
ShriHarsha Uppaluri, University of Nebraska-Lincoln
Ronald Cerny, University of Nebraska - LincolnFollow
Stephen G. DiMagno, University of Nebraska-LincolnFollow

Date of this Version

2010

Citation

Org Lett. 2010 August 6; 12(15): 3352–3355.

Comments

Copyright © 2010 American Chemical Society

Abstract

The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to “scale down” to the conditions used typically for radiotracer synthesis.