Improved Arene Fluorination Methodology for I(III) Salts

Authors

• Bijia Wang, University of Nebraska-Lincoln
• Linlin Qin, University of Nebraska-Lincoln
• Kiel D. Neumann, University of Nebraska-Lincoln
• ShriHarsha Uppaluri, University of Nebraska-Lincoln
• Ronald Cerny, University of Nebraska - LincolnFollow
• Stephen G. DiMagno, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2010

Citation

Org Lett. 2010 August 6; 12(15): 3352–3355.

Comments

Copyright © 2010 American Chemical Society

Abstract

The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts. This methodology is shown to “scale down” to the conditions used typically for radiotracer synthesis.