The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

Authors

Raul Alvarez-Venegas, University of Nebraska-Lincoln
Monther Sadder, University of Nebraska-Lincoln
Andrej Hlavacka, University of Bonn, Kirschallee 1, D-53115 Bonn, Germany
Frantisek Baluska, University of Bonn, Kirschallee 1, D-53115 Bonn, Germany
Yuannan Xia, Genomics Core Research Facility
Guoqing Lu, University of Nebraska-Lincoln
Alexey Firsov, University of Nebraska-Lincoln
Gautam Sarath, University of Nebraska-LincolnFollow
Hideaki Moriyama, University of Nebraska-LincolnFollow
Joseph G. Dubrovsky, Universidad Nacional Auto´noma de Me´ xico, Apartado Postal 510-3, Cuernavaca Morelos, CP 62250, Mexico
Zoya V. Avramova, University of Nebraska-LincolnFollow

Date of this Version

4-3-2006

Comments

Published in PNAS April 11, 2006 Vol. 103 no. 15 6049-6054. Includes supplemental supporting information.

Abstract

TheArabidopsis homolog of trithorax, ATX1, regulates numerous functions inArabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

Includes supplemental supporting information.